The objective of the present study was to develop once-daily sustained-release matrix tablet of fluvastatin, an antihyperlipidemic drug. The tablets were prepared by the dry granulation method. The tablets were evaluated for various physicochemical parameters, in-vitro drug release, swelling and erosion studies and stability. At lower polymer concentration, the erosion front movement was found to be more than diffusion front and drug release was anomalous as compared to zero order kinetics at higher concentration. The HPMC: HPC and MCC based test formulation (HM4) was expected to compete with the reference standard for bioequivalence and bioavailability. An extended release hydrophilic matrix tablet of a water soluble drug fluvastatin was prepared successfully by dry granulation method.
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